The relevance of medicine information through education and counselling empowers patients in decision making, which can ultimately improve patient outcomes. A study conducted in Finland indicated that parents’ source of information regarding their children’s medicine use regardless of the age was from health professionals, mostly from the physician and from patient information leaflet. Parents further indicated that information obtained from health care professionals including physicians and pharmacist were found to be reliable. In this study, similarly, majority of participants with hypertension and diabetes both in rural and urban communities mostly sought medicine information from the nearest health institutions. Results of this study differ slightly from a study conducted in the US where patients with rare disease conditions used physicians and the internet more often as their medication information source. Male patients were found to use their spouse/partner more often than did female patients. Female patients however, were more likely to use medication package inserts and the internet and were less likely to use nurses than were the male patients. A study conducted among Arabic speaking Australians revealed that there was limited access to verbal and written medication and disease information, hence the over-reliance on health care practitioners who do not provide quality and adequate information. The need to obtain reliable and valid information is very critical for patients who have non-communicable diseases, hence the source of medicine information should be acknowledged as an important tool in improving patient outcomes, as adherence to medication will usually be based on information obtained from the health professional. The source of medicine or drug information for patients is usually preferred from the physician, while the pharmacist is mentioned as the second preferred source. This assertion was confirmed in this study as participants in both the rural and urban communities indicated they obtained medicine information from the nearest health institution, while the pharmacy was the second preferred choice. Further analysis to determine what influenced participants’ choice using the multinomial logistic regression test revealed association of increasing age, educational level attained and marital status in both urban and rural communities. Increasing age of participants, increased the relative odds of seeking information on medicines from a family member, friend health professional and nearest health institution than a pharmacy, and less likely for married participants to seek medicine information from a friend health professional in urban communities. This is similar to studies that propose that the physicians are a key source of medicine information. In the rural communities, married status and educational level obtained by participants with hypertension and diabetes increased the likelihood to source information on medicines from a friend health professional; also increasing age and educational level, were likely to source information from the nearest health institution than the pharmacy. The participants with low socio-economic status in rural communities preferred to obtain medicine information from the nearest health institution than the pharmacy. This could be as a results of pharmacies are not closer to the rural folds and they to travel a long distances to access them. However, in the urban communities none of the enabling factors shown statistical significance with medicine information.